Caffeine addiction is such a downer that regular coffee drinkers may get no real  pick-me-up from their morning cup, according to a study by British  scientists.
Bristol University researchers found that drinkers develop a  tolerance to both the anxiety-producing and the stimulating effects of caffeine,  meaning that it only brings them back to baseline levels of alertness, not above  them.
"Although frequent consumers feel alerted by caffeine, especially  by their morning tea, coffee, or other caffeine-containing drink, evidence  suggests that this is actually merely the reversal of the fatiguing effects of  acute caffeine withdrawal," wrote the scientists, led by Peter Rogers of  Bristol's department of experimental psychology.
The team asked 379  adults -- half of them non/low caffeine consumers and the other half medium/high  caffeine consumers -- to give up caffeine for 16 hours, and then gave them  either caffeine or a dummy pill known as a placebo.
Participants rated  their levels of anxiety, alertness and headache. The medium/high caffeine  consumers who got the placebo reported a decrease in alertness and increased  headache, neither of which were reported by those who received  caffeine.
But measurements showed that their post-caffeine levels of  alertness were actually no higher than the non/low consumers who received a  placebo, suggesting caffeine only brings coffee drinkers back up to  "normal."
The researchers also found that people who have a genetic  predisposition to anxiety do not tend to avoid coffee.
In fact, people in  the study with a gene variant associated with anxiety tended to consume slightly  larger amounts of coffee than those without it, Rogers wrote in a study in the  Neuropsychopharmacology journal, published by Nature.
This suggests that  a mild increase in anxiety "may be a part of the pleasant buzz caused by  caffeine," he said.
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